Senior Scientist, Translational Cytomics, Hematology R&D
AstraZeneca

Job Info

---

Senior Scientist, Translational Cytomics, Hematology R&D

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. We are more than one of the world's leading pharmaceutical companies.

AstraZeneca has a multifaceted environment that cultivates collaboration and innovation. We attract top minds, and we nurture and build talent.

Within Hematology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of multiple scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs.

The Translational Medicine (TM) function exists within Hematology R&D to ensure effective and strategic biomarker studies for Hematology & Oncology project teams. Closely interacting with the pre-clinical BioScience and Discovery, Early Clinical Development, and Precision Medicine & Biosamples diagnostics functions, the Hematology Translational Medicine team is the single point of accountability for delivery of robust, scientifically-driven biomarkers to all Hematology project teams, providing feasibility assessments, technical validation, centralized biomarker analysis capability for clinical samples, delivery of translational science research and early clinical phase engagement. We are looking for a highly motivated scientists to join Translational Research, Haematology R&D team and work in close collaboration with the Center for Single Cell Studies (CSCS) in Waltham Massachusetts.

Key Responsibilities and Accountabilities

• Preparing, and executing procedures of single-cell RNA sequencing using different types of specimens.
• Optimization of methods for single cell/nuclei sequencing from fresh and archival clinical samples and solve problems during the process.
• Transition of new technologies from proof-of-concept to standardized workflows.
• Delivery of reliable and high-quality data and metadata to computational analysis.
• Assist with bulk NGS experiments as required.
• Synergize with Translational Research Scientists, Translational Medicine Leads and computational biologists.
• This is a laboratory-based position.

Qualifications:

• Ph.D. in biological sciences with NGS laboratory experience, or M.S. in biological sciences with 2+ years NGS laboratory experience.
• Hands-on experience in single cell RNA sequencing techniques required, with exposure to spatial transcriptomics approaches preferred: specimen handling, quality control assessments, droplet-based cell processing, library construction and sequencing.
• Familiarity with theory and operations of platforms such as Chromium with preference to additional familiarity in theory and operations of Visium, Xenium and similar platforms.
• Deep understanding in immunology, cancer, genomics, and RNA biology.
• Solid track record of performance, including successful completions of projects within a given timeframe and budget.
• Outstanding ability to work independently and with a team- including problem solving, brainstorming, integrating data and helping other team members.
• Excellent organizational and documentation skills.
• Excellent data presentation skills.
• Innovative approach and enthusiasm to explore new technologies.

Preferred:

• Mastery of R-based or Python-based analysis of single cell NGS and bulk NGS data.

Working at AstraZeneca

Here you'll have the chance to create a substantial difference to patients' lives! With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines - for the world's most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and crafting the patient ecosystem.

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park Bio Hub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers.

Our Waltham site offers a variety of amenities help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.

As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release

"When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world."

Next Steps? Apply now!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Find out more and follow AstraZeneca on:

LinkedIn https://www.linkedin.com/company/1603/

Facebook https://www.facebook.com/astrazenecacareers/

Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

---