Scientist/Senior Scientist in the new Therapeutic Genome Engineering (TGEn) group
St. Jude Children's Research Hospital

Job Info

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Overview

At St. Jude Children’s Research Hospital, talented faculty and staff work together and with colleagues worldwide-to advance the research and treatment of pediatric cancer and other catastrophic diseases. St. Jude is anticipating hiring a Scientist or Senior Scientist in the summer months. We are seeking outstanding, highly motivated, and creative candidates for scientist roles in the new Therapeutic Genome Engineering (TGEn) group that is part of a multidisciplinary team of scientists and clinical researchers to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. Our ongoing therapeutic pipeline is fueled by internal scientific discoveries academic collaborations. Come join TGEn to enGENEer concepts to cures.  You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children’s Research Hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells. You will have the opportunity to learn about and support new exciting projects such as:

• Development and optimization of pre-clinical genome editing strategies to treat hemoglobinopathies and other hematological diseases.
• Process development and IND-enabling studies (Pharm/Tox)

  Apply today! A cover letter is highly recommended.
Responsibilities

• Perform studies to develop genome editing strategies of human hematopoietic stem cells. 
• Design and execute IND-enabling experiments to characterize the pharmacology of a genome edited human hematopoietic stem cell product to treat sickle cell disease. 
• Characterize the efficacy and potency of the cellular drug product in in vitro and xenotransplantation assays. 
• Interact and collaborate with multidisciplinary team to advance the program. 
• Evaluate scale-up and close-system processes to ensure reproducibility of drug product. 
• Exploratory research on developing novel in-vitro and in-vivo delivery strategies.
• Establish tracking and trending analyses of process development and pilot runs. 
• Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility. 

Minimum Education

Bachelor's degree in relevant scientific area is required.PhD in Life Sciences, Bioengineering, or related discipline is preferred.
Minimum Experience

Scientist:

Seven (7) years of relevant post-degree work experience is required

Five (5) years of relevant post-degree work experience is required with a Master's degree

Three (3) years of relevant post-degree work experience is required with a PhD

 Senior Scientist:

Ten (10) years relevant post-degree work experience is required

Eight (8) years of relevant post-degree work experience is required with a Master's degree

Six (6) years of relevant post-degree work experience is required with a PhD

  Minimum Experience:

• Strong experience and knowledge in hematology and hematopoietic stem cell biology.
• Experience in cell-based therapy culture and process. 
• Experience with genome editing tools (Nucleases/base editing/prime editing) 
• Ability to communicate effectively with strong communications skills and a collegial personality. 
• Ability to operate in a fast-paced, multi-disciplinary environment. 
• Strong molecular biology skills for cloning and mRNA production
• Must be an independent thinker, meticulous, detail-oriented, and analytical. 
• Must be highly motivated, have excellent organizational, communication and interpersonal skills. 
• Must be able to work independently and as part of a multi-disciplinary team. 

Preferred Experience:

• Knowledge of process development concepts for biological manufacturing; basic principles of various engineering disciplines.
• Bioengineering or materials science experience in delivery technologies.
• Experience in NGS sequencing and data analysis.
• Familiarity with flow cytometry; analysis and sorting.
• Animal experience, familiar with humanized mouse xenotransplantation models (NSG/NBSGW) 

Other Information

St. Jude is an Equal Opportunity EmployerNo Search Firms:St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.COVID-19 vaccine:St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.  Apply to be a part of the mission of St. Jude Children's Research Hospital: to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. Consistent with the vision of our founder Danny Thomas, no child is denied treatment based on race, religion or a family's ability to pay.  F1390

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