Postdoctoral Researcher Mechanisms and applications of bacterial immune systems Santiago-Frangos Lab
Location: Philadelphia, PA
Open Date: Jan 29, 2024
Deadline:
The Santiago-Frangos lab seeks a motivated and enthusiastic postdoctoral fellow to work in a multidisciplinary team on cutting edge research that determines how immune systems (e.g. CRISPR) function, and that repurposes these mechanistic insights for biotech applications. Relevant research includes our papers published in NSMB and Nat. Comms., and a patent on a CRISPR-based diagnostic. More info can be found at: https://web.sas.upenn.edu/sanfrango-lab/research/.
The postdoctoral fellow will have the opportunity to work on up to two research arms in the lab, that aim to determine how i) bacterial and archaeal CRISPR adaptive immune systems make DNA-based memories of past phage infections, and ii) how CRISPR-generated nucleotide messengers signal an immune response. Candidates interested in biotech applications of CRISPR-mediated immunity are also invited to apply.
Project scope will be tuned to the fellow's interests and skills. Broadly: i) Use a combination of sequence- and structure-based comparative approaches to discover novel biochemical activities and biological functions, or ii) develop biochemical assays to test bioinformatics-based hypotheses, and determine the structures of large protein and protein-nucleic acid complexes using cryo-EM.
Lab and Institution Overview
The Santiago-Frangos lab integrates bioinformatics, biochemistry, and structural biology to address complex biological and biotechnological questions (https://web.sas.upenn.edu/sanfrango-lab/). The Santiago-Frangos lab values Curiosity, Open communication, Integrity, a Growth mindset, and Diversity, Equity and Inclusion. We are located in a large and newly renovated (2024) space at Leidy Labs within the Biology Department at the University of Pennsylvania (UPenn). Research in the Santiago-Frangos lab is supported by the NIH and the Burroughs Wellcome Fund.
All UPenn schools are located on a single compact campus, with no laboratory or faculty office more than a 12-minute walk away - fostering a multidisciplinary approach to education, scholarship, and research. Candidates will have access to many well-funded and equipped core research facilities including: Cryo-Electron Microscopy Facility, Bioinformatics Core, High-Throughput Screening Core, Johnson Foundation Biophysical Structural Biology Core, The Biological Chemistry Resource Center, and the Penn Microbial Culture and Metabolomics Core.
Postdoctoral Fellow Responsibilities:
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