Associate Scientist Bioscience Immunology, Early Respiratory and Immunology
AstraZeneca

Job Info

Associate Scientist Bioscience Immunology, Early Respiratory and Immunology (level B)

AstraZeneca is a global, science-driven biopharmaceutical company. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. The vision of AstraZeneca Early Respiratory & Immunology is centered on delivering life-changing products that advance world health and help fight and cure disease. Early Respiratory & Immunology is one of three main therapeutic research areas within AstraZeneca that deliver candidate drugs into late-stage clinical development. Here, you'll have the opportunity to make a difference in people's lives every day.

We are looking for an Associate Scientist to join our growing Early Immunology and Autoimmunity group. Candidate will help support development of novel drug target ideas from concept to preclinical work. Lab based position will support and collaborate with a research team to develop target biology and promote project progression. Areas of disease interest include Lupus, Inflammatory Bowel Disease and Rheumatoid Arthritis research. Areas of research interest include understanding of autoimmune interferon pathway regulation, myeloid cell activation, tissue damage/repair and autoimmune disease modeling.

Main Duties and Responsibilities

This job is a lab-based research role, and you will have significant opportunity to drive the direction of the work. The work will be predominantly human in vitro systems, working with primary and disease tissue-derived cells, although knowledge and experience of in vivo science is a bonus. A background in human immunology and immune-mediated diseases and translational approaches to understand basic biological mechanisms in disease is needed.

Essential Skills:

- Master or Bachelor's degree in immunology or relevant discipline-Autoimmune/Immunology experience.

-Expertise in drug discovery projects in the immunology or a closely related field of biology is preferred

-Highly organized and self-motivated, with the ability to work independently as well as collaboratively within a team to conduct a high-level research project.

-Strong hands on skills in basic biochemical and molecular techniques including in primary human cell cultures, cell line culture, quantification of mRNA (qPCR) and protein expression, ELISA, Western Blotting, and Flow Cytometry assays.

-Attention to detail and excellent ability to summarize, record, and present research findings

- High level of enthusiasm for innovative scientific research leading to the discovery and development of novel therapeutics.

Desirable Skills:

-In vitro immunology/autoimmune model development, MSD, IHC/histology, confocal microscopy imaging and analysis experience.

-Stem cell/organoid culture experience.

-Next generation sequencing (RNAseq/ATACseq) sample preparation and data analysis experience.

-In vivo skills are a strong plus, association with in vivo models of autoimmunity and inflammation are preferred but not essential.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.